A large number of antibiotics in the pharmaceutical market forces a careful approach to their choice. The same drug can not be used more often than once every 3-6 months. This is due to the fact that there is an addiction to the body. Therefore, modern manufacturers are releasing new products that can have the desired effect, even if the time difference between the diseases was less. One of these drugs is Fromilide. Thanks to its wide spectrum of action, it can cope with most known microorganisms. How to use it, what should I look for when taking this drug? About this in the article below.
Product Description
The study of any drug begins with instructions for use, with "Fromilidom" should do the same. In it, the manufacturer indicates the main parameters that are required for preliminary study. So, it contains information regarding the fact that the drug belongs to the group of macrolides semi-synthetic antibiotics. The medicine has a prolonged effect, when it enters the gastrointestinal tract, the absorption of the component occurs gradually.
What does the release form consist of
In the instructions for use with tablets "Fromilid 250 mg" contains the content of the active ingredient - clarithromycin. Accordingly, the lower the number, the lower the content of the basic substance. This allows you to choose the right dosage or get rid of the need to take the drug several times a day, it will be possible to do with one reception. Auxiliary components help to preserve the active substance in tablet form. The manufacturer also offers a longer-acting drug, which is produced under the name “Fromilide Uno”, which has a dosage of 500 mg.
In addition to tablets, this drug is available in the form of granules and powder for the preparation of a suspension. It is well tolerated by children and therefore doctors often prescribe it as the main medicine for the treatment of respiratory diseases.
Pharmacological properties
Clarithromycin inhibits protein biosynthesis by binding to 50S ribosome subunits in sensitive bacteria. According to the instructions for use with Fromilide, the action of the main component is detrimental to gram-positive and gram-negative anaerobic, as well as aerobic bacteria and microorganisms (for example, mycoplasma, some types of staphylococcus, chalamidia, streptococcus). Hospital strains, mycobacteria, spirochetes, campylobacteria can also be attributed to this.
Mode of application
The instructions for use with Fromilide say that it should be taken with food without chewing. In uncomplicated forms of the disease, it is recommended to observe a dosage of 500 mg per day. If we are talking about a complex disease, a serious infectious inflammatory process, the number of tablets can be doubled, having previously agreed upon the need for such a regimen for taking the medicine with your doctor.
Taking the drug in a lower dosage (250 mg) will require doubling the frequency of administration. The average duration of the course of treatment takes from 5 to 14 days, depending on the indications for use.
If we talk about granules for the preparation of a suspension, it is necessary to take into account the weight of the patient. In particular, with regard to children weighing up to 8 kg, then for them the dosage is calculated on the basis of 7.5 ml of suspension per 1 kg of weight. Next, you need to add 2.5 ml. In order to properly prepare the solution, it is recommended to follow the instructions for use for Fromilid suspension: to do this, take 42 ml of boiled water at room temperature, ¼ is added to the bottle with granules. The manufacturer advises pre-shaking the container so that the particles stick together. The resulting solution is shaken until the granules are completely dissolved. The bottle contains a mark to which it is necessary to add the rest of the water.
When prescribing the drug, older children or adults are not recommended to chew the granules, as they have a bitter taste.
Indications for appointment
According to the instructions for use with Fromilide, tablets are prescribed for the treatment of diseases caused by the development of infections that are sensitive to the effects of clarithromycin. These diseases include:
- Lesions of the upper and lower respiratory tract (for example, pneumonia, sinusitis, tonsillitis, bronchitis, pharyngitis, sinusitis and others).
- Otitis.
- Affected by soft tissue of the skin (folliculitis).
- Preventative therapy.
This can also include some skin diseases, for example, erysipelas.
Contraindications
According to the instructions, the use of Fromilid for children under 12 years of age is unacceptable when it comes to tablets. In newborns up to 6 months, the suspension is also contraindicated. Other barriers to taking the drug include:
- Hypokalemia.
- Fructose intolerance (for example, 125 mg of granules for the preparation of a suspension contains 1.6 g of fructose, which is a contraindication for use in patients with this component intolerance).
- Individual intolerance or hypersensitivity to this group of antibiotics.
Patients who have such a chronic disease in a serious form, such as kidney failure, cannot take Fromilide as a medicine. There are also contraindications for prescribing this drug to pregnant women and women who are breastfeeding.
The use of the drug simultaneously with statins is contraindicated. They can trigger the development of myopathy, including rhabdomyolysis. If the patient is prescribed “Fromilide”, then taking other drugs that have statins in their composition must be temporarily stopped. In extreme cases, their dosage should be significantly reduced.
Drug overdose
If we talk about cases when the amount of the daily norm of “Fromilid” is exceeded, then there is a risk of overdose symptoms. This may be an upset gastrointestinal tract. As in most cases, when a similar phenomenon occurs, it is recommended to immediately wash the stomach.
What you should pay special attention to
Instructions for use with "Fromilid" in 500 mg tablets contain a detailed list of circumstances that you should pay attention to before starting a course of treatment. Since this tool refers to antibiotics, it is necessary to observe the duration of the drug. Excessive use of clarithromycin reduces the sensitivity of fungi and bacteria. This is fraught with the fact that superinfection may develop, which will require taking a stronger drug.
At the first sign of a malfunction in the liver, Fromilide manufacturer recommends discontinuing use, since reversible hepatitis with jaundice may develop.
Side effects
In the instructions for use with Fromilid 500 mg, the manufacturer indicated the need to monitor the reaction of the body. Most often, after taking a course of antibiotics, indigestion and diarrhea occur, as the intestinal microflora is disturbed. At the same time, there are cases when a headache, drowsiness, dizziness, swelling of the face, candidiasis occurred.
If you look at the instructions for use for the suspension "Fromilid 250/125 mg", then the list of adverse reactions is similar to that attached to the tablets. As for infants, it is necessary to monitor the condition of the child. At the first signs of an allergic reaction, deterioration of health, the appearance of anxiety, it is recommended to inform the doctor and review the dosage of the drug. In extreme cases, there is a chance of a complete cancellation of this drug and the appointment of another treatment regimen, in agreement with the pediatrician.
Interaction with other drugs
Instructions for use of Fromilide include an indication of which drugs can interfere with the absorption of clarithromycin. Caution should be exercised while taking ototoxic drugs simultaneously with Fromilide. It is recommended to monitor the functioning of the vestibular apparatus during treatment. Patients who need prior consultation before starting treatment also include those who have a history of heart disease, especially ischemic. While taking clarithromycin and Warfarin, it is important to monitor blood counts such as prothrombin time and INR. This is due to the fact that the risk of developing severe bleeding increases.
When it comes to treating pneumonia, it is important to consider the body's sensitivity to the perception of this antibiotic by the body. For this, a test is carried out previously and only then it is recommended to purchase this drug.
Women taking oral contraceptives can continue to take them and at the same time undergo treatment using Fromilide 500. Instructions for use have a reservation only for those hormonal drugs that are not included in this category, since there is a risk of severe adverse reactions from the body. Therefore, the doctor needs to be informed about which medicines the patient is taking at the time the medication is prescribed.
What can be replaced, briefly about analogues
Those who need the Fromilide analogue should pay attention to the main component in the instructions for use. It is for this substance that they are looking for a replacement for this or that drug. Including dosage form. Since in this case we are talking about clarithromycin, it is worth separately highlighting its eponymous analogue with a similar name. It is also available in the form of tablets and powder for suspension. Users recommend purchasing it if Fromilide is not available in the pharmacy chain. You can safely take a course of treatment with the drug, the effect will be the same.
"Claricin" refers to drugs that are similar in active ingredient. Available in the form of tablets, 250 and 500 mg, and for children under 12 years of age in the form of a suspension. There are a number of similar drugs that are considered to be generics, as they have the active substance in the form of clarithromycin: Klabaks, Binaklar (tablets of 250 mg), Criksan, Ekozitrin (they contain lactulose).
The complex preparation “Arvitsin” contains 2 tablets in a package with a dosage of 500 mg of clarithromycin, 4 capsules with amoxicillin, 2 enteric capsules with omeprazole. The manufacturer of this medicine also offers longer-acting tablets Arvitsin Retard, which have a dosage of 500 mg of the main active substance.
Reviews of patients and doctors
On the Web you can find a lot of reviews about the use of Fromilide. The instructions indicate its wide spectrum of action of the drug against most harmful bacteria. Therefore, first of all, it is necessary to check what is written there. But, do not lose sight of the fact that the medicine was very effective for most patients. Users note the onset of a positive effect. It is worth emphasizing that it is necessary to go through the entire course of treatment, even if in the process the patient felt relief.
Doctors recommend taking antibiotics with caution. If the symptoms of the current disease are close to those noted earlier, it may happen that at the moment this drug will not be effective. This is due to the fact that the microorganism once encountered with this antibiotic during a repeated illness will no longer be susceptible to its action.