Complex edema of the soft tissues, which are poorly amenable to localization, provoking point disturbances in the blood supply system and accompanied by pain, is a rather serious challenge for the pharmacological industry. Injuries of this kind are most often the result of surgical and postoperative interventions, or the result of mechanical damage to the musculoskeletal system, brain and / or spinal cord (volume hematomas, complications of compression fractures in the form of progressive swelling, etc.).
High-quality therapy and effective prevention of edema-pain syndrome is the “area of responsibility” of diuretics, glucocorticoids, flavonoids, ergot alkaloids, as well as medications obtained from the fruits of ordinary horse chestnut. In the latter case, “Lysine estsinate” is of particular interest, the analogues of which, despite the similarity of the pharmacological action algorithm, sometimes cannot provide the necessary therapeutic effect.
The reaction of the body to the active substance
Lysine Aescinat classifies the instructions for use as a multifunctional angioprotector. The components of the drug, reacting with the cells of the body, reduce the likelihood of large-scale inflammation, quench the sensitivity of pain receptors and slow the progress of swelling in the tissues (up to a complete stop of the exudative processes).
This result is possible due to inhibition of lysosomal hydrolases, which are responsible for the rate of cleavage of mucopolysaccharides inside the blood lines and in adjacent connective tissues. Moderate hypoglycemic manifestations and a general increase in vascular tone against the background of normalization of their permeability is a logical result of the dosed use of this medication.
Indications for the prescription of the drug
“Lysine escinate” (the instruction presents it as one of the forms of the composite association of horse chestnut triterpene saponins) is prescribed if:
- diagnosed with swelling of the brain / spinal cord of a severe and critical degree of development (including when the presence of intracranial hematomas with displacement is confirmed);
- local soft tissue edema was detected that affects the functioning of the musculoskeletal system (the patient has acute pain during movement / physical exertion, and damaged areas of the body are supplied with blood in an atypical manner);
- suspicions regarding acute thrombophlebitis were justified (there is an imbalance in the venous circulation of the legs, further exacerbated by edematous inflammatory processes).
"Lysine Aescinat": instructions for use and recommended dosage
The use of the medication implies unhurried intravenous administration (the setting of an intra-arterial dropper is strictly prohibited). The optimal daily dose for adults is 5-10 ml of the drug, diluted with 0.9% sodium chloride solution (volume of NaCl - 15-50 ml). However, in cases of a real threat to the patient’s life (usually with progressive brain edema) , an increase in the daily norm to 20 ml of the active substance is permissible (two doses within 24 hours, 10 ml each). The maximum dose is 25 ml / day.
For children and children, Lysine Aescinate instructs to administer in such quantities:
- child age 1-5 years: 0.22 mg per kilogram of body weight;
- age 5-10 years: 0.18 mg / kg;
- age 10-15 years: 0.15 mg of the drug per kg;
- age 15-18 years: 0.12 ml / kg.
The preparation of the active solution, that is, the dilution of the drug with sodium chloride, should be done immediately before use. The total duration of therapy should not exceed 8 days (the course can be reduced to two days if the attending physician considers that the patient's condition has stabilized before the specified time).
Clinical trial results
"Lysine estsinat" application instruction is positioned as a drug that has undergone clinical trials and has shown high efficiency in the fight against edema of various origin. So, in particular, in patients with a traumatic brain tumor, after administering the medication through a dropper, a significant reduction in the area of inflammation was observed. Along the way, the structure of the edema also changed: the undamaged areas ceased to compress, which helped to accelerate the stabilization of pressure inside the cranium. It was also noted that timely injections of Lysine Aescinat, made in the form of a smooth infusion with a slowdown in injection, often prevented the development of the above scenarios and favorably affected the patient's well-being.
The suppression of inflammatory reactions at the initial stage and the prevention of volumetric swelling is reflected in the stimulation of the functional activity of the brain, that is, in minimizing the regression of nerve endings.
Special Terms of Use
Despite the fact that the reviews of specialized specialists are mostly positive about Lysine Escinat, there is no reliable information on the reaction of active components to the fetus during pregnancy (a similar situation exists with breastfeeding of newborns). Therefore, it is not recommended to prescribe a drug in such cases.
In addition, special attention should be given to patients with a diagnosis of hepatocholecystitis - escinate plays the role of a natural catalyst for transaminases and can slightly load the liver. However, in the absence of other pathologies, this disease is not a reason for discontinuing the drug.
Side effects and contraindications
In addition to pregnancy and lactation, the instructions for use impose the following prescription restrictions on the drug "Lysine Escinat":
- individual intolerance to components;
- acute renal failure ;
- serious problems in the liver;
- internal bleeding (ulcers or other forms of erosion of organs and tissues).
Subject to the above conditions, allergic reactions to the drug are extremely rare. Nevertheless, they are not excluded:
- skin: itching, urticaria, the formation of bright "blush" on the face;
- nervous system: tremor, alternating with convulsions, acute, undamped headaches, fainting;
- Gastrointestinal tract : nausea, sometimes diarrhea and vomiting;
- biliary system and liver: short-term increase in the activity of bilirubin and transaminases;
- blood vessels and heart: hypotension and hypertension, arrhythmia;
- respiratory organs: shortness of breath, severe dry cough.
Quite often, side effects are poorly expressed, which complicates the diagnosis of allergies. For example, general weakness or fever can be perceived not as a result of intravenous administration of the drug, but as a result of a cold.
The nature of the interaction with other medicines
“Lysine estsinate” (patient reviews about this medicine, as a rule, come down to the topic of complications in the musculoskeletal system, since they cannot evaluate the therapeutic effect of brain injuries, due to the criticality of the situation) refers to alcohol-containing compounds. Therefore, it is necessary to select drugs for simultaneous use in course therapy with increased caution (alkaloids can neutralize active substances).
Contact of escinate with aminoglycosides is undesirable. The reason lies in the increased toxicity of the reagents. The presence of anticoagulants in the prescription forces you to review the dosage of the drug in the direction of decreasing the daily norm. But the combination with analgesics and antimicrobial agents is going well (the anti-inflammatory properties of escinate are amplified due to the absence of additional loads on organs and systems).
Release form and description
Being a representative of the group of angioprotectors, the drug “L-lysine escinate,” reviews of which are sometimes subjective and do not reflect the real picture of what is happening, is produced in the form of a clear, colorless solution. In this case, 1 ml of liquid contains 0.001 g of active substance. The role of auxiliary components is assigned to propylene glycol, ethyl alcohol and specially prepared (injection) water.
Overview of Alternative Drugs
The trade name of the described drug is Lysine Aescinat.
Analogs similar in pharmacological action are presented below:
- “Furosemide” (tablets / solution) - the fight against edema-pain syndrome in hereditary diseases of the cardiovascular system, the elimination of swelling in areas of the brain / spinal cord (hematomas of mechanical origin), the stimulation of urine output, etc.
- "Hypothiazide" (tablets) - for edema caused by congenital heart failure, cirrhosis, hypertension.
- “Valusal” (tablets / capsules / cream / solution) - for localization and neutralization of musculoskeletal degenerative processes, relief of postoperative pain syndrome, etc.
Lysine Aescinat: reviews of doctors and patients
Edema of the interhemispheric tissues and swelling of the substance of the brain is evidence of severe traumatic brain injury. According to experts, in such a situation, the structural displacement of the cortex, which leads to disability or death, is a matter of several hours, and sometimes minutes. To stabilize the situation, dehydration therapy is usually performed. However, corticosteroids, saluretics and osmotics - the most common "tools" of exposure - often provoke side effects or do not justify the expectations placed on them.
According to practicing neurosurgeons, an alternative drug should be Lysine Aescinat (instructions, expert reviews and important nuances regarding the method of drug use are given above). Unlike analogues, the injection solution does not cause critical complications and precisely hits the target, thereby ensuring control of the dynamics of swelling (minimizes the volume of swelling of the brain / spinal cord).