Pills "Tolperizon" are included in the group of muscle relaxant drugs. The medication has a central effect. The medicine has membrane stabilizing activity, slows down neuromuscular conduction in motor neurons and afferent primary fibers. This provokes the blocking of poly- and monosynaptic spinal reflexes. The drug inhibits the conduct of excitation in the reticulospinal path of the brain stem. Regardless of the effect of the central nervous system, the drug increases peripheral blood flow. The development of this effect may be due to the antiadrenergic and antispasmodic effects of the drug. When used orally, the drug is well absorbed from the small intestine. After half an hour, a maximum of an hour, the maximum content of the drug in the plasma is noted. Due to persistent pronounced metabolism, the bioavailability of the drug is 20%. The breakdown of the drug occurs in the kidneys and liver. In the form of metabolites, 99% is excreted in the urine.
The medicine "Tolperisone." Instructions for use. Indications
The drug is prescribed for increased (pathologically) tonus and cramps in striated muscles associated with neurological organic pathology, with pyramidal lesions , stroke, multiple sclerosis, encephalomyelitis, including myelopathy. The medication “Tolperizon” recommends the use of it as a rehabilitation treatment after operations in traumatology and orthopedics. Indications include increased tone and muscle spasm, muscular contractures that complicate pathologies in the musculoskeletal system. In particular, the medication is effective for lumbar and cervical pain syndrome, arthrosis in large joints, spondylarthrosis, spondylosis. In combination with other means, the Tolperizon preparation recommends the use of the drug in the treatment of vascular diseases of the obliterating type.
Such indications include
Raynaud's disease, thromboangiitis,
diabetic angiopathy, atherosclerosis. The drug is prescribed for diseases provoked by disorders in the innervation of blood vessels: angioedema intermittent dysbasia, acrocyanosis.
Medication "Tolperizon". Instructions for use
The drug is taken in an initial dose of 50 mg no more than three times during the day. Gradually, an increase in the amount of medication is carried out to 150 mg 2-3 r. / Day. Duration is set individually, taking into account the nature of the course of the disease and the severity of the patient's condition.
Contraindications
Pills "Tolperizon" (reviews of experts confirm this) are not prescribed for myasthenia gravis, under the age of 18 years, intolerance to the components. Contraindications include periods of lactation and pregnancy. Due to the presence of lactose in the medicine, a medication is not recommended for intolerance or deficiency of this substance.
Means "Tolperizon". Instructions for use. Adverse reactions
The medicine provokes headaches, muscle weakness, nausea, gastralgia (passes with a lower dosage). Arterial hypotension, an allergic reaction due to intolerance, occurs due to treatment.