Suppositories "Flexen" belong to the pharmaceutical group of NSAIDs (non-steroidal anti-inflammatory drugs). They have anti-inflammatory, antipyretic, analgesic and anti-aggregation effects. The presented drug blocks the activity of enzymes (cyclooxygenases 1 and 2) and the synthesis of prostaglandins. This process prevents the formation of inflammatory mediators and inhibits the appearance of leukotrienes.
Flexen suppositories exhibit anti-bradykinin activity, stabilize lysosomal biomembranes, and inhibit neutrophil activity in patients diagnosed with rheumatoid arthritis. Suppress platelet aggregation. The analgesic effect is due to both central and peripheral mechanisms. Many doctors prescribe Flexen (candles) to relieve pain and treat arthritis. The price of the drug allows you to purchase it for different categories of patients. Reviews about the medication indicate its high effectiveness and safety for health, subject to the relevant recommendations.
The instructions for using the medication are quite simple, and reviews confirm the visible therapeutic effect. What is included in the medication? What properties does it possess? Are there dangerous side effects? The answers to these questions are sought by many patients.
The chemical composition of the drug
The composition of the drug includes a complex of bioactive and auxiliary substances:
- ketoprofen (a major bioactive compound);
- beeswax;
- hydrogenated vegetable oil;
- silicon dioxide colloidal;
- sodium ethyl parahydroxybenzoate;
- sorbitol;
- gelatin;
- vegetable oil;
- glycerol;
- soya lecithin;
- titanium dioxide;
- sodium propyl parahydroxybenzoate.
"Flexen", candles: analogues
In therapeutic practice, doctors quite actively use analogues of the above drug:
- "Arthrosilen."
- Ketonal Duo.
- "Artrum."
- "Bystrumgel."
- Valusal
- Bystrumkaps.
- Ketonal.
- "Oruvel".
- "Febrofit."
- Flamax.
- "Profenid."
- Ketonal Uno.
Benefits of the drug
The main advantages of the medication include the following indicators:
- maximum therapeutic effect;
- high bioavailability of the drug compared to its analogues.
Drug shortcomings
The main disadvantages of Flexen include the following criteria:
- high price of the drug in comparison with analogues;
- there is no daily (prolonged) form of release.
Pharmacokinetics
The binding of bioactive substances of the drug with plasma proteins is 99 percent. Candles "Flexen" are characterized by high bioavailability (more than 90%). The therapeutic concentration of Flexen in the blood lasts for 6 hours. The main metabolic cleavage of the drug occurs in hepatocytes by glucose. The half-life is about two hours. The drug is not cumulated, excreted mainly by the kidneys and through the intestines.
"Flexen" (candles): instructions for use, price
The above drug exhibits a wide therapeutic spectrum of action. In clinical practice, in the treatment of pain and inflammatory reactions of various origins, "Flexen" suppositories are often prescribed. The use of the drug is recommended for the following pathologies:
- migraine;
- psoriatic arthritis;
- tenosynovitis;
- renal colic;
- gouty arthritis;
- bursitis;
- dorsalgia;
- myalgia;
- rheumatoid arthritis;
- otitis;
- osteoarthrosis of various localization;
- rheumatic polymyalgia;
- bone pain
- sciatica;
- phlebitis;
- ankylosing spondylitis;
- neuralgia;
- thrombophlebitis;
- radiculitis;
- adnexitis;
- pathology in the lumbosacral plexus;
- sciatica;
- algodismenoria;
- postoperative and post-traumatic syndrome ;
- lymphangitis;
- pain syndrome in oncological pathologies.
To buy the drug "Flexen", the price of which varies in the range of 200-300 rubles, if you have a prescription, you can at any pharmacy. It is also worth noting that the "Flexen" candles in gynecology are quite often used, they are prescribed for ovarian cysts. According to many patients, the medicine works quite effectively. Many doctors claim that after treatment with "Flexen" for 10 days and the subsequent intake of additional drugs, the cyst disappears.
Contraindications
If you decide to use "Flexen" (candles), the instructions for use indicate that this medication should not be used in the following cases:
- bleeding in the gastrointestinal tract;
- severe dysfunction of the liver and kidneys;
- lactation period and pregnancy;
- hypersensitivity to non-steroidal anti-inflammatory drugs;
- hemorrhoids;
- "Aspirin" asthma;
- bleeding disorders ;
- proctitis;
- age up to 15 years;
- hematopoietic system dysfunction (leukopenia, hemocoagulation disorders, thrombocytopenia, hemophilia);
- digestive tract diseases in the acute phase.
Special instructions
“Flexen” (suppository) instructions show that patients with kidney, liver, digestive tract, bronchial asthma, alcoholism, rhinitis, polyps on the nasal mucosa, dehydration, urticaria, smoking, cirrhosis, hyperbilirubinemia, blood diseases, should be prescribed with extreme caution sepsis, diabetes mellitus, cerebrospinal pathologies, the elderly. In the process of treatment with this medication, systematic monitoring of kidney and liver function is necessary. If Flexen suppositories are prescribed together with anticoagulants (heparin), the risk of bleeding increases. A long therapeutic course is possible only in a hospital setting. During treatment, avoid drinking alcohol.
Side effect
Is Flexen assigned to you (candles)? Instructions for use do not exclude the development of side effects. It:
- severe headaches;
- nausea;
- heartburn;
- dizziness;
- vomiting
- decreased appetite;
- insomnia;
- gastrointestinal hemorrhages;
- asthenia;
- drowsiness;
- conjunctivitis;
- xerophthalmia;
- nervousness;
- constipation;
- noise in ears;
- forgetfulness;
- blurred vision;
- hepatitis;
- hearing loss;
- vertigo;
- peripheral neuropathy;
- gastralgia;
- tachycardia;
- transient dysuria;
- hyperemia;
- eczema;
- cystitis;
- nephrotic syndrome;
- urethritis;
- photodermatitis;
- laryngeal edema;
- hematuria;
- exudative erythema;
- kidney dysfunction;
- edematous syndrome ;
- itchy skin;
- skin allergies;
- increased activity of aminotransferases (alanine and aspartate aminotransferases) in blood serum;
- dyspnea;
- rhinitis;
- nose bleed;
- bronchospasm;
- anaphylactic shock.
Using suppositories can also cause diarrhea, a burning sensation, and tenesmus.
Symptoms in case of drug overdose
Suppositories "Flexen" are intended for rectal use - 1 suppository (100 mg) 1-2 times a day. The maximum allowable daily dose of ketoprofen is 300 mg. With an overdose of the drug, the following symptoms are observed:
- liver and kidney dysfunction;
- drowsiness;
- nausea;
- bleeding;
- severe pain in the epigastric region;
- vomiting
If the above signs are detected, symptomatic therapy is prescribed. There are no specific antidotes. Activated charcoal, Sorbex, Medetopec or Neointestopan are prescribed as adsorbents. Hemodialysis, forced diuresis - ineffective methods of treatment. Alkaline preparations are prescribed to relieve symptoms of the digestive canal. If necessary, glucocorticoids can be used. With renal failure, hemodialysis is performed. In case of seizures, “Diazepam" or other benzodiazepane anticonvulsants are prescribed; with severe hypotension, plasma substitutes are administered (Reopoliglyukin, Polyglyukin, Enterodez, Polydez, Hemodez). The patient requires constant monitoring for several days, since there is a danger of a later manifestation of some gastrointestinal pathologies (bleeding, ulceration).
Interaction with other medicines
It enhances the effect of anticoagulants, fibrinolytics, ethanol, antiplatelet agents, reduces the effects of peripheral vasodilators, spironolactone, the effectiveness of uricosuric medicines, antihypertensive pharmaceuticals and diuretics. The above medicine is incompatible with Tramadol. The combined use of "Flexen" with other non-steroidal anti-inflammatory drugs, ethyl alcohol, glucocorticosteroids, corticotropin provokes the formation of ulcers and the development of gastrointestinal bleeding. Antacids reduce the effectiveness of absorption of the drug. Two days before the test for the content of 17-ketosteroids, the drug is canceled.
"Flexen" increases the hypoglycemic effect of insulin, as well as oral hypoglycemic drugs. Myelotoxic drugs increase the hematotoxicity of the drug. Inducers of microsomal biooxidation in the liver (Phenylbutazone, ethanol, tricyclic antidepressants, Phenytoin, Rifampicin, barbiturates) activate the biosynthesis of hydroxylated active metabolites. The simultaneous use of "Flexen" with "sodium valproate" causes a violation of platelet aggregation.
Reviews about the drug
Many patients are interested in the question of what Flexen candles really are. Instructions for use, the cost of the drug, indications and contraindications are, of course, the main points. Nevertheless, it is worth getting acquainted with the opinions of specialists and patients in this regard. Most doctors believe that the best analgesic and anti-inflammatory drug is Flexen (candles). Patient reviews in most cases (from 80 to 90%) are positive, due to the high effectiveness of the drug, reliable relief of pain of various etiologies and localization, long-lasting effect, as well as ease of use. A positive effect can be noted already from the first days of admission. Negative reviews about the drug are mainly associated with the appearance of side effects and its cost, however, such disadvantages of the drug are not able to overshadow its high effectiveness.
Pharmacy Vacation Terms
The drug in the form of suppositories and capsules is dispensed strictly by prescription. A drug in gel form may be dispensed without a prescription.
Storage conditions
Keep out of reach of children at temperatures not exceeding 25-30 ° C. The specified temperature regime applies to all forms of release. The expiration date is indicated on the package. The medication should not be taken after the expiration date!