The medicine "Safocide" is a combination agent containing secnidazole, fluconazole, azithromycin. The medication exhibits antifungal, antiprotozoal and antibacterial effects. Fluconazole is able to selectively inhibit the synthesis of sterols in fungal cells. Its activity is manifested in relation to microspores, cryptococci, trichophytosis, candida. Azithromycin belongs to the category of azalide antibiotics.
This substance has a bactericidal effect, creating high concentrations in the foci of inflammation. Azithromycin acts on mycoplasmas, chlamydia, neisseria, gardnerella, streptococcus, ureaplasma, treponema. The component does not affect gram-positive microflora resistant to erythromycin. Secnidazole has antiprotozoal, antimicrobial activity. The component does not affect aerobes. Secnidazole provokes sensitization to alcohol-containing compounds, increases the sensitivity of tumors to the effects of radiation. The mechanism of component activity is determined by the ability to destroy the helical structure of DNA, suppress the synthesis of nucleic acids, which contributes to the breakdown of bonds and death of bacterial cells.
The drug "Safocide". Instructions for use. Appointment
Indications include combined lesions of the genitourinary system of the infectious type, transmitted through sexual contact. A medication is prescribed for cystitis, urethritis, gonorrhea, chlamydia. The drug is recommended for vulvovaginitis, cervicitis, bacterial vaginosis, trichomoniasis, fungal infections of the reproductive system.
Contraindications
The drug "Safocide" (instructions for use warns about this) is not recommended for pathologies of the central nervous system of the organic type, intolerance of its components, as well as during pregnancy. Do not prescribe a remedy at the same time as taking such medicines as Terfenadine, Astemizole, and others, which contribute to lengthening the QT interval. Contraindications also include lactation.
Side effect
The negative effects of therapy with Safocid include instructions for the use of a taste disorder, heart rhythm disturbance, and digestive system activity. The drug can trigger flatulence, epigastric pain, stomatitis, skin reactions, nausea. In some cases, diarrhea, vomiting, anaphylactic shock, dizziness, or headaches are noted.
Dosage regimen of the drug "Safocide". How to take the drug
The drug is prescribed inside. There are four tablets in the blister, they are taken once. It is recommended to drink the drug two hours after or one hour before eating.
Additional Information
Against the background of therapy with Safocide (the instructions for use contain such data), while using it with Warfarin, an increase in the prothrombin index by an average of 12% can be noted. When receiving coumarin anticoagulants, it is necessary to provide control over changes in prothrombin time. During therapy, consider slowing down the rate and volume of absorption when eating.