Means "Streptomycin". Instructions for use

The drug "Streptomycin" is an antibiotic. The medication has a wide spectrum of antimicrobial activity. The action of the drug is effective against tuberculous mycobacteria, a large number of gram-negative (against E. coli, pathogens of brucellosis, tularemia, plague and others) and a number of gram-positive (staphylococci) microorganisms. Less activity is observed in relation to pneumococci, streptococci. Anaerobes, viruses, rickettsia are resistant to the drug.

The drug has a bactericidal effect. The mechanism of action is based on the ability to inhibit protein synthesis in the pathogen cell. Poor absorption of the drug is noted when taken orally, with intramuscular effect, absorption is better. An hour or two after ingestion, the drug reaches its maximum concentration. Excretion mainly through the kidneys. Streptomycin tablets are not manufactured. The medication is produced in forms intended for intramuscular, intracavernous, intratracheal administration, as well as in the form of an aerosol.

Indications

The medicine is recommended for use in the treatment of pulmonary tuberculosis . The medication is also indicated for purulent inflammatory processes of various localization, provoked by the activity of gram-negative, gram-positive, sensitive to the active substance microbes. In particular, the medicine is prescribed in combination with drugs:

• "Levomycetin" - with pneumonia due to Klebsiella;
• "Tetracycline" - with tularemia and plague;
• with other antibiotics - with brucellosis and endocarditis.

Dosage regimen

Intramuscularly, the Streptomycin medication, the instructions for use recommend the use of 0.5-1 g, but the dose should be no more than 2 g per day. With a weight of less than fifty kilograms and after the age of 60, 0.75 mg per day is administered. For children, the dosage is 15-20 mg / kg, but not more than 0.5-1 g per day. With tuberculosis, the drug is administered once. In case of poor tolerance, the drug is divided into two doses. The duration of therapy is determined by the condition of the patient and the course of the pathology. Treatment can last more than three months. With lesions of non-tuberculous nature, the total dosage is divided into three to four injections. The interval is 6-8 hours. The duration of treatment is 7-10 days.

Medication "Streptomycin". Instructions for use: contraindications

Do not prescribe medication for lesions of the vestibular and auditory apparatus, severe cardiovascular insufficiency, and renal dysfunction. Contraindications include pregnancy, disorders in the cerebral circulation, lactation, obliterating endarteritis. Means "Streptomycin" instruction for use does not recommend prescribed for myasthenia gravis, hypersensitivity. Mixing the medicine in the same syringe with penicillin group medicines and cephalosporins is not allowed.

Means "Streptomycin". Instructions for use: adverse reactions

During therapy, patients have various allergic and toxic negative manifestations. The most severe of these experts include lesions of a number of cranial nerves and, as a result, hearing impairment and vestibular disorders.