According to the instructions for use, the medicine "Veroshpiron" belongs to the category of diuretics aimed at preserving potassium in the body. The tool is sold in most modern pharmacies, it costs about 70 rubles per package. Veroshpiron is available in tablet form, intended for oral administration.
Release Forms
There are three dosage options for the active compound in one tablet: 25, 50, and 100 mg. The optimal release, suitable for a particular case, is chosen by the doctor on the basis of the particular case. The instructions for Veroshpiron 25 mg, 50 mg, 100 mg specify that the medication is based on spironolactone. It is the amount of this compound in one capsule that reflects the concentration figures.
In addition to the main substance in the manufacture of tablets, the manufacturer used auxiliary components. The complete list that is specific to a particular product must be studied if a person has an allergic reaction or intolerance to any compound common in the pharmaceutical industry. In particular, as indicated in the instructions for the use of Veroshpiron tablets, the medicine contains lactose in the form of a monohydrate, intolerable to a certain group of people. Also used are starch, silicon dioxide and magnesium stearate.
What's on sale?
Tablets are packaged in blisters placed in a cardboard box. On the package, the name of the medication and the company that made it, as well as the nuances of the dosage and the number of copies in one pack, must be indicated. The manufacturer recalls that it is permissible to sell the product only upon presentation of a prescription from a doctor.
Inside the package, in addition to the medicine, there is always an instruction for Veroshpiron tablets. It is necessary to get acquainted with it before the initial use of the drug. In the future, you will have to follow both the limitations of the instructions and the recommendations of the doctor. If the rules are not followed, the use of the composition can provoke negative consequences, side effects, and worsening of the patient's condition.
Pharmacology
In the instructions for the medicine "Veroshpiron", the manufacturer indicates that the drug belongs to potassium-sparing diuretics. This substance is an aldosterone antagonist. Under its influence, the activity of aldosterone in the tubules of the kidneys slows down, which affects the processes of preservation of fluid, sodium, potassium in the body. Since aldosterone receptors are suppressed, sodium ions and chlorine are more actively excreted with urine, but the excretion of hydrogen and potassium ions decreases.
The diuretic effect explains the effect on pressure, confirmed by numerous reviews by cardiologists. In the instructions for use of Veroshpiron, the manufacturer also focuses on pressure correction: indicators are reduced due to diuretic effects.
The diuretic effect is maximum seven hours after taking a single dose of the drug. The duration of the effectiveness of one dose is 24 hours or more.
Kinetics of the drug
The manufacturer clarifies in the instructions of Veroshpiron (50 mg, 25 and 100 mg of any dosage) that the absorption processes are fast and their efficiency is close to 100%. Absorption is localized in the gastrointestinal tract. The use of medication every day in a standard dosage (100 mg) for 15 days allows you to achieve a maximum concentration of the active compound - 80 ng / ml. Such indicators are recorded on average 2.6 hours after taking the pill. For the active metabolite of the active compound, the maximum concentration is achievable after 3.2 hours, its performance is about 391 ng / ml. Another active derivative (canrenone) is observed in the greatest amount in the blood after 4.3 hours. Its parameters are 181 ng / ml.
The level of entry into strong complexes with plasma proteins is about 90%. The active compound of the drug and its transformation products are able to penetrate the placenta. The instructions for use of Veroshpiron (25 mg, 50 and 100 mg) specify that fractions of the drug are detected in breast milk.
Transformation and Elimination
In the instructions to Veroshpiron, the manufacturer mentions that the transformation processes are fast enough. The area of localization is the liver. Processing products are two active compounds.
The main substance of the drug, as well as its metabolic products, are eliminated with urine. A relatively small percentage of compounds is excreted during bowel movements with feces. The half-life of the main product is quite short, is 1.3 hours on average. The half-life of metabolic products varies from three to eleven hours. Daily use of Veroshpiron for two or more weeks at a dosage of 100 mg allows to achieve a half-life of spironalactone of 1.4 hours, and metabolites -13.8-16.5 hours.
When will it help?
A full list of indications for the use of the composition is provided by the manufacturer in the instructions accompanying Veroshpiron tablets. It is specified here that the remedy is effective in heart failure, accompanied by congestive phenomena, if other diuretics do not bring results or their effectiveness is too weak, as well as with increased arterial pressure of an essential type. This is often diagnosed with a lack of potassium in the body. The considered agent for this diagnosis is usually used in combination with other drugs to control pressure. Also, the medicine can be used to correct a lack of potassium in the body, if safer therapy options are not applicable for a particular case.
According to the instructions for use, Veroshpiron is recommended for hyperaldosteronism, swelling due to nephrotic syndrome, as well as hepatic cirrhosis, in which the patient suffers from ascites, edema.
The described drug is widely used as a prophylactic if the risk of hypokalemia is assessed as very high, while patients undergo cardiac glycoside therapy.
How to use?
The optimal dose and frequency of administration will be recommended by the doctor at the reception, issuing a prescription for Veroshpiron. The instructions for use clarify the need to use the medication orally after a meal. The drug is taken per day once or twice. If you are supposed to use a daily dose at a time, you should do this in the morning. When dividing the daily volume into two servings, the first is used for food in the morning.
If the need for admission is explained by primary hyperaldosteronism, the patient is prescribed an operation, during the preparation for it, the drug is used in an amount of 100-400 mg. If the operation is postponed, it is allowed to use the drug for a long course to maintain the patient's condition. The minimum effective dose for a particular case is selected. The initial volumes are used for two weeks, then every two weeks they reduce the amount of the substance, figuring out which minimum volume is sufficient. Long-term use of the composition is more effective in combination with other diuretics - this helps to reduce the likelihood of side effects.
Nuances and diagnoses
In the instructions to Veroshpiron, the manufacturer indicates the effectiveness of the use of the composition in edematous syndrome caused by various pathological conditions. For adult patients, the optimal dosage is 100 mg, but in some cases it may increase or decrease in the range of 25-200 mg. The drug is used once or twice. When prescribing more than 100 mg per day, it is recommended to combine the substance with other diuretics that affect other sections of the renal tubules. This will require adjustment of the volumes of the composition under consideration.
Using "Veroshpiron" according to the instructions for hepatic cirrhosis with ascites, edema, it is necessary to first pass an examination to detect the concentration of electrolytes. If the ratio of sodium to potassium ions in urine is more than one, at first no more than 100 mg of the substance is prescribed for the day. If the ratio is less than one, the initial dosage for the day is 200 mg, the maximum is twice as much. For a supportive course, the volumes of the drug are selected, focusing on the individual characteristics of the case.
Pressure and electrolyte balance
According to the instructions, Veroshpiron is effective in case of essential increased pressure in arteries. With this diagnosis, the drug in question and other medicines should be combined to control indicators. Initially, 50-100 mg are prescribed per day, used in 1-2 doses. The duration of such a program is 14 days. By the end of the second week, you can record the maximum effect on pressure. Based on the results obtained, the dosage is adjusted individually.
With a low content of potassium in the body, the instructions for use "Veroshpiron" is recommended in an amount of 25-100 mg per day. The drug is used only when safer methods of restoring potassium content do not give results. Initially, potassium medicines, potassium supplements, and other similar techniques should be tried. When the lack of result is proven, resort to Veroshpiron.
Nuances and individual cases
According to the instructions for use, Veroshpiron is allowed for children in a dosage calculated on the basis of the patient’s weight: 1-3 mg of the drug per kilogram. The received dose is taken at a time or divided into two doses. If the drug is chosen as an element of maintenance therapy, combined with other diuretic compositions, the dosage is reduced to 1-2 mg per kilogram.
When choosing a program for the treatment of elderly people, at first, Veroshpiron is recommended in the lowest possible dosage as an instruction for use. Gradually increase the volume until you can achieve the maximum desired result.
In the treatment of persons suffering from renal or hepatic impairment, special care must be taken. It must be remembered that such failures affect the processes of transformation and elimination of the drug.
Alternative: are there any analogues?
The instructions for use of Veroshpiron clarify that the product works due to the presence of spironolactone in the composition. Medicines are based on the same compound:
- "Spironolactone."
- "Urakton."
- Spyrix.
In some cases, the drugs Aldacton, Spironol become the optimal replacement.
If it is impossible to purchase the prescribed drug, you must consult a doctor for the selection of the optimal replacement. Self-correction of a course recommended by a doctor can cause program inefficiency or activation of negative side effects. If it was decided to replace the drug in question with an analogue of Veroshpiron, the instructions for the selected remedy will also have to be studied before using the medication.
Is it worth it to spend money?
People taking the drug leave a lot of reviews about Veroshpiron tablets. In the instructions for use, the manufacturer indicates the need for a diuretic strictly under the supervision of a doctor. As can be seen from the responses about the drug, it was the people who used the medication at the insistence of the doctor who received a pronounced positive result, achieved stabilization of pressure with minimal negative consequences.
At the same time, there are negative opinions about the performance of Veroshpiron. Mostly these are expressed by persons who used the drug at their own discretion. It is noted that it caused negative consequences for pressure, destabilized the work of some internal systems and organs, including the digestive.
Negative consequences: what is possible?
In the instructions for use of Veroshpiron, the manufacturer indicates that in a fairly high percentage of cases, patients using the medication experienced an excessive accumulation of potassium in the body, which requires extremely careful attention to following the rules developed for the medication. There is a higher likelihood of hyperkalemia in the elderly, diabetics, and patients taking ACE inhibitors. In rare cases, sodium deficiency, dehydration and porphyria, alkalosis and acidosis were observed.
In a small percentage of cases, thrombocytopenia, megaloblastosis occurred. Other disorders of the blood-forming organs are possible. Some patients were sick and dizzy, confused, they were drawn to sleep. There is a risk of ataxia, paralysis. Possible arrhythmia, lowering the pressure above normal. Sometimes, taking pills, she feels sick and vomits, hurts in the stomach, develops gastritis or ulcer, bleeding, hepatitis. There is a risk of kidney failure in the acute form, decreased reproductive function, tenderness of the mammary glands. When using the drug in an increased dosage, the likelihood of infertility is high.
In a predominant percentage of cases, negative effects disappear on their own as the course of treatment is completed.
Strongly impossible!
It is forbidden to use Veroshpiron in case of anuria and inadequate kidney function in acute form, as well as in cases of severe malfunctioning of this organ, when creatinine clearance is estimated at less than 10 ml / min.
"Veroshpiron" is prohibited with an excess of potassium in the body, a lack of sodium. You can not use the composition while carrying a child and breastfeeding, as well as for the treatment of children under the age of six. "Veroshpiron" is not suitable for people suffering from Addison's disease, as well as those who have been found to be hypersensitive to any component of the drug. Do not use tablets if genetic fructose intolerance, lack of lactase, or malabsorption syndrome has been identified.
If there is a need to use the medication during breastfeeding, the child should be transferred to an alternative form of nutrition.
Important Features
The use of “Veroshpiron” in case of impaired hepatic functionality requires careful attention to the patient due to the possible correction of transformation processes, removing the medication from the body. In case of kidney failure in acute form, the drug is not used. Do not use a diuretic if creatinine clearance is less than 10 ml / min.
For pathologies, diseases that cause an increased risk of acidosis, potassium excess, Veroshpiron is used very carefully, since the risk of such conditions is significantly higher. The risk of excessive accumulation of potassium against the background of nephropathy in diabetics is increased.
The use of Veroshpiron may cause a transistor increase in the concentration of urea nitrogen in the plasma. This is more common for people whose kidneys are malfunctioning, as well as suffering from hyperkalemia. There is a chance of reversible acidosis occurring in one of the scenarios: metabolic or hyperchloremic.
Safety and intricacies of use
“Veroshpiron” and alcohol are not strictly combined. For the entire period of treatment with the drug, you will have to give up alcohol.
The use of a diuretic can lead to disruptions in the detection of digoxin, epinephrine, cortisol in the blood plasma.
The manufacturer recommends at the beginning of the therapeutic course to exclude from everyday life the management of transport and other devices and machines that require an increased concentration of attention. The duration of the refusal depends on the condition of the patient and is selected individually in each case.
You can notice excessive intake of the composition by craving for sleep. The patient is confused. Laboratory tests show an imbalance of electrolytes and fluids in the body. There is no specific antidote. If an overdose is detected, the doctor chooses therapy based on the symptoms.