Maninil is one of the representatives of the class of drugs that lower sugar. It is used to support the required amount of glucose in the blood. In our article, we will consider in detail the instructions for use with Maninil. In addition, we find out what analogues he has, and also find out what patients write about their admission in their reviews.
Drug release form
What does the instruction for this medication tell us? The basic active component of this medication is glibenclamide. Excipients of the drug are components in the form of methyl hydroxyethyl cellulose, lactose monohydrate, potato starch, magnesium stearate and silicon dioxide.
The drug is presented in the form of pink tablets. Depending on the dosage, one tablet contains from 3.5 to 5 milligrams of the main active substance.
In pharmacies, this medicine can be bought with a prescription. For the drug "Manin" the budget price is one hundred and seventy rubles. This drug does not require any special storage conditions. True, access to children along with direct sunlight will have to be limited. The shelf life of these tablets is three years, the expired drug is only subject to disposal.
Now we turn to the testimony of "Manilin" and find out in which cases the use of this drug is appropriate.
Indications for the use of a medication
According to the instructions for use with Maninil, these tablets are prescribed to diabetics as a supplement in the absence of the expected effect after a lifestyle modification. That is, this drug is prescribed if a low-carb diet, along with adequate physical activity, correction of excess weight, control of the emotional state and compliance with the rest regimen does not help.
This medicine is prescribed by an endocrinologist who calculates the treatment regimen. At the same time, the diet is taken into account along with the patient's age, stage of the disease, concomitant pathologies, general well-being and the body's response to the drug. Dosage is determined depending on the glycemic profile of the patient. It is important to understand that self-medication is unacceptable. This is fraught with grave consequences.
Instructions for use "Maninil"
The starting dose is usually prescribed as a minimum, namely, patients are prescribed half a 5-milligram tablet per day. Particular attention in the framework of dosage adjustment is given to asthenic patients who have a hypocaloric diet. Also, those patients who have a history of hypoglycemic attacks deserve special attention. And also adjustment is required for people who are engaged in heavy physical labor. In the first seven days of taking the drug, glycemic control is mandatory. Dosing titration is carried out according to the testimony of the meter and at the discretion of the doctor. The therapeutic norm for taking Maninil is 15 milligrams per day, which is three tablets of 5 milligrams or five pills of 3.5 milligrams each.
In cases of replacement of other hypoglycemic drugs with Maninil, they are guided, first of all, by the starting dose. Immediately after the cancellation of previous drugs, the values of the glucometer are clarified along with the results of urine analysis. The reaction of the body is checked by a minimum dosage of 3.5 or 5 milligrams. A diet with other conditions of a healthy lifestyle is a must. To avoid side effects, the dosage of a new medicine is increased gradually. A diabetic must report any changes in well-being to his attending physician.
What else does the instructions for use with Maninil tell us?
Recommendations for use
It is recommended to use this medication in the morning before breakfast. The medicine is best washed down with a glass of plain water. In order to achieve the maximum therapeutic effect, it is advisable to take the drug at the same time. In the event that the time of admission is missed, two doses cannot be combined together in any case. The dosage of Maninil must be strictly observed.
The duration of therapy is determined by the endocrinologist. Glycemic monitoring results should be recorded by the patient in the diary of a diabetic.
Side effects of using the drug
In humans, the following side effects of Maninil may occur:
- The occurrence of hypoglycemic attacks along with obesity.
- The occurrence of disorders of accommodation and perception.
- The presence of dyspeptic abnormalities and changes in the rhythm of bowel movements.
- Increased alkaline phosphatase.
- The appearance of a rash such as dermatitis, which is accompanied by itching.
- Reducing platelet count in blood plasma.
- Reducing the number of red blood cells with white blood cells.
- The occurrence of transient proteinuria and sodium deficiency.
During adaptation to the drug, visual disturbance is usually observed, which passes on its own, without any medical intervention. The occurrence of dyspeptic disorders in the form of attacks of vomiting, nausea and diarrhea do not require replacement of the drug and eventually disappear spontaneously.
The occurrence of skin allergic reactions is usually reversible. From Manilin tablets the allergy can be manifested by chills, and at the same time fever, symptoms of jaundice and the appearance of protein in urinalysis. In such situations, consultation with your doctor is required.
In separate examples, the reduction of all blood components is recorded immediately. After the drug is canceled, such changes do not pass quickly. Cross-allergy may occur with other medications that provoke hypersensitivity in patients. In particular, the dye E124, used in the manufacture of this medicine, serves as a powerful allergen.
Next, we find out in which cases the medicine “Maninil” is not suitable for treatment.
Contraindications to the use of the drug
It is worth noting that this medication is not prescribed if patients have hypersensitivity to its ingredients. In addition, it is not suitable for use in the following cases:
- If patients have allergies to diuretics and any sulfonylurea-based medications.
- This drug is not suitable for treatment if the patient has metabolic acidosis.
- With a diabetic coma.
- Pregnant women.
- Patients with severe liver and kidney dysfunctions.
- In the presence of alcoholism, since in this case there is a threat of hypoglycemia.
When carrying out abdominal operations and in the presence of severe injuries and extensive burns, taking antidiabetic tablets, such as Maninil, is strictly prohibited. They are temporarily replaced by insulin, which allows you to easily and quickly adjust the concentration of sugar in the blood plasma.
There is no absolute prohibition on driving with these pills. But it is worth considering that hypoglycemic attacks can significantly impair attention along with thought processes, especially in the framework of complex treatment with sugar-lowering drugs. In this regard, each diabetic should assess the degree of risk for himself independently.
Drug interaction
With concurrent treatment with Maninil, Glibenclamide and Clonidine, as well as adrenergic blockers or Guanethidine, the symptoms of impending hypoglycemia may be masked, which will not allow to predict a diabetic coma. Regular intake of laxatives, which provoke an upset stool, lowers your glucose meter, increasing your chances of making hypoglycemia.
It inhibits the activity of Maninil and provokes a hyperglycemic state, the simultaneous use of Acetazolamide, Diazoxide, barbiturates and diuretics. A similar effect is produced by nicotinates, rifampicin antibiotics, sympathomimetics, medications based on female hormones, and preparations for the thyroid gland.
Medicines in the form of “Ranitidine”, “Pentamidine” and “Reserpine” act unpredictably and act as catalysts or inhibitors of the activity of “Maninil”.
How to replace this medication, we will tell below.
Help with an overdose from this medication
An overdose of this drug can provide severe hypoglycemia with a lasting effect, and in addition, severe and life-threatening symptoms of the victim are possible. Every diabetic can recognize the clinical manifestation of a hypoglycemic attack correctly:
- The occurrence of uncontrolled hunger.
- The appearance of tremors of the arms and legs.
- The development of tachycardia.
- Increased anxiety.
- Blanching of the skin and mucous membranes.
Sometimes a temporary disorder of consciousness may occur, as well as paresthesia. In the event that the victim is not provided with emergency medical care, he may fall into a hypoglycemic precoma or coma, which is very dangerous death.
Diagnosis of such consequences begins with the collection of information about the patient from his relatives who are familiar with medicines that were taken by a diabetic patient. Also, doctors need information about concomitant diseases of the patient. The examination is carried out in laboratory conditions.
Inspection of the victim makes it possible to assess his condition. The temperature may be lowered. Depending on the severity of the seizure, muscle spasms may occur in the tonic or clonic type. In addition, non-standard reflexes are possible along with convulsions.
In the event that the victim is still conscious, he should drink sweet tea with sugar, eat fast carbohydrates such as sweets or cookies. If the condition does not stabilize, then the diabetic is hospitalized. In the presence of a coma in the hospital, a forty percent glucose solution (40 milliliters) is administered. Under the monitoring of analyzes, infusion therapy is adjusted by means of low molecular weight carbohydrates.
In medicine, there are known cases of hypoglycemic seizures that were caused by the cumulative capabilities of Maninil. Such cases require observation of patients in a hospital with regular monitoring of glycemia and symptomatic treatment. In the event that the victim took the extra pills by accident and the condition against an overdose is tolerable, then it is enough to rinse the stomach and give absorbents with a glass of sweet tea.
Analogues of Maninil
Exactly the same active substance is present in Glibenclamide and Glibamide. These drugs can easily replace the drug we are describing. Indications along with contraindications and side effects are absolutely identical.
Analogues of Manilin can also be such drugs as Glidiaba, Gliclazide, Diabeton and Glyurenorm. These medicines are similar to him in their therapeutic effect.
Additional recommendations for the use of funds
For patients in adulthood, and in addition, for people with hypocaloric nutrition, as well as asthenics and diabetics with concomitant kidney diseases, the starting dose of Manilin is reduced to a minimum, since there are possible risks of developing hypoglycemia. In the event that the diabetic has changed his weight, then the lifestyle, along with his treatment regimen, is also being reviewed.
Patients with senile dementia, as well as those who have mental disorders and other conditions that complicate the full contact of the patient with the doctor, require great attention. Laboratory examinations of this category of people should take place more often. In order to assess the characteristics of the effects of this drug on the body, analogues with accelerated release of active components are preliminarily prescribed.
In the event that the diabetic does not absorb Metformin, then he is prescribed medications of the glitazone group in the form of Rosiglitazone or Pioglitazone. If appropriate, Manilin tablets are also supplemented with alternative antidiabetic drugs with a different mechanism of action. Guarem, along with Acarbose, which, like Maninil, stimulate the pancreas, are not used in complex therapy.
Long-term use of the drug “Maninil” depletes the cells of the body, leads to necrosis, and against this background, insensitivity to this drug develops. In order to support the pancreas, diabetics are transferred to insulin. This is done in whole or in part, depending on the degree of atrophy.
Reviews on this drug
The reviews about Maninil are mixed. Doctors call it a traditional hypoglycemic medication with a powerful evidence base of safety and effectiveness.
As for patients, they are not satisfied with guaranteed weight gain along with various side effects. But most patients find this drug effective, and people write in reviews of Maninil that it helps them after many other drugs have been helpless.
Despite the fact that many people say that they have recovered from the drug, there are reviews in which, on the contrary, it is stated that patients did not notice a similar effect while taking this medicine.
Report on the effectiveness of "Manil" and in people of advanced age. It is noted that for such patients, this drug helps to keep sugar normal, even though they do not move much.