Why is it necessary to use a tool like Indocollyr? Instructions for the use of this medication, as well as its contraindications, indications and side effects will be described in the materials of this article. From it you will also learn about the form in which the medicine in question is released, what is included in its composition, whether there are analogues for this drug, etc.
The composition of the drug, its packaging, release form
In what form is a drug such as Indocollyre produced? Instructions for use state that it is 0.1% eye drops. The sterile solution is transparent and practically colorless. One ml of a medicinal substance contains 1 mg of indomethacin. In addition, the composition of the medication also includes such additional components as hydrochloric acid, thiomersal, hydroxypropylbetacyclodextrin, arginine and purified water.
The drug "Indocollyr" (eye drops) goes on sale in dropper bottles made of polyethylene, which are placed in cardboard boxes.
Pharmacodynamics of the drug
How does the drug "Indocollyr" (eye drops)? The instruction that is enclosed in the package along with the medicine informs that it is an anti-inflammatory non-steroidal drug intended for local use. Apply such a tool in ophthalmology. It has not only anti-inflammatory, but also analgesic properties.
The main mechanism of action of the drug in question is the inhibition of prostaglandin synthesis. By the way, it is the latter that play a crucial role in the pathogenesis of pain and inflammation.
Pharmacokinetic characteristics
Is Indocollyr (eye drops) absorbed? The instruction for this medication contains data that the said agent penetrates the anterior chamber of the visual organ. After a single installation, the active component is determined after a few hours. However, it should be noted that with local use of the drug, its systemic absorption is small.
Indications
For what purposes do doctors prescribe the drug “Indocollyr” (eye drops)? The instruction informs that this product has the following indications for use:
- prevention and treatment of inflammatory processes that occur after surgery on the eyes (eyeball) ;
- inhibition of myosis with cataract surgery;
- non-infectious conjunctivitis treatment ;
- prevention of edema of the macula (cystic) that arose after cataract surgery;
- prevention and treatment of post-traumatic inflammation in non-penetrating as well as penetrating wounds of the apple of the eye (in addition to local antimicrobial treatment).
Contraindications
Under what conditions should the patient in no case be prescribed Indocollyr (eye drops)? Instructions for using this tool indicate the following contraindications:
- hypersensitivity to acetylsalicylic acid, as well as other non-steroidal drugs, which is manifested by attacks of bronchial asthma, the appearance of acute rhinitis and urticaria;
- hypersensitivity to drug substances.
It should also be noted that the drug in question is prescribed with extreme caution for herpetic keratitis (epithelial) and diseases that cause the process of blood clotting disorders (including hemophilia, tendency to bleedings and prolonged bleeding time).
The drug "Indocollyr" (eye drops): instructions
The price of the funds in question will be presented a little further. As for this section, in it we will tell you about how and in what dosage the Indocolly medication should be used.
In order to inhibit intraoperative myosis, an ophthalmic drug is prescribed 1 drop in the conjunctival sac for 2 hours with an interval of half an hour (i.e. 4 times). Such procedures must be carried out immediately before surgery.
To prevent such a deviation as cystic edema of the macula, the medication is used 1 drop four times or three times a day for 1 month. Such procedures should be carried out after surgery.
For other indications, eye drops are usually prescribed 1 drop 4 times a day (depending on the severity of the patient's condition). The course of therapy can last from 1 to 4 weeks.
It should be especially noted that the accidental administration of the drug inside does not cause the development of any side effects.
Drug interaction
Can Indocollyr eye drops be used simultaneously with other medical devices? According to experts, this medication enhances the effects of lithium preparations and indirect anticoagulants.
It is extremely undesirable to use the medicine in question at the same time as Diflunizal, as this can lead to the development of bleeding from the digestive tract. In addition, eye drops should not be used with other non-steroidal drugs, including acetylsalicylic acid (especially in high doses).
The simultaneous use of indomethacin with saluretics and beta-blockers can significantly weaken the therapeutic effects of the latter.
If the agent in question must be used simultaneously with other drops, including those containing GCS, then the interval between instillations should be at least 5 minutes (in order to prevent the active elements of the drug from being washed out in subsequent doses).
Lactation and pregnancy
Is it possible to use the eye drops “Indocollyr” during the gestation, the price of which will be presented below? Strictly controlled and adequate clinical studies regarding the safety of the use of the drug in question during lactation and during pregnancy have not been conducted. Although experts say that this medication can be used in the first 5 months of bearing the fetus. But this is only if the expected benefit for the mother significantly exceeds the possible risk for the baby.
Starting from the 6th month of pregnancy, the use of eye drops is prohibited. This is due to the fact that they can easily lead to disruption of the kidneys and vascular system in the fetus.
As is known, indomethacin is excreted along with breast milk. In this regard, if it is necessary to use the drug during breastfeeding, it is necessary to resolve the issue of stopping lactation. Otherwise, medication should be avoided.
Side effects
Can the Indocollyr drug adversely affect human health? The analogs of this medicine and the eye drops themselves can really cause undesirable effects. So, on the part of the organs of vision in patients, a moderate or mild burning sensation (in the eyes), as well as a loss of (temporary) clarity of vision (observed immediately after using the drops) are very rarely observed. With prolonged use of the drug, conjunctivitis and corneal opacity may occur in humans.
As for allergic reactions, the drug "Indokollir" rarely provokes the appearance of itching and redness of the skin.
It cannot be said that with prolonged use of eye drops, the patient may develop systemic side effects of indomethacin.
special instructions
What should the patient be informed about before prescribing Indocollir eye drops? Before instilling the drug, contact lenses must be removed. Installing them back is allowed only after ¼ hours after installation.
After each use of the drug, the dropper bottle must be tightly closed. It is also not recommended to touch the tip of the pipette to the organs of vision.
Does the Indocollir drug affect the ability to control various mechanisms and drive vehicles? Those people who temporarily lose their clarity of vision after instilling a medication, it is undesirable to drive a car, as well as to work with complex and dangerous equipment (for example, with machines, elevators) or any other equipment that requires a clear vision.
Holiday conditions and shelf life of the drug
Eye drops "Indocollyr" are dispensed in pharmacies without a medical prescription. This medicine belongs to the list B. The medicine should be stored only in a place inaccessible to small children. The storage temperature of such a drug should not be higher than 25 ° C. Shelf life is 2 years. After this period, the droplets should be discarded.
After opening the dropper bottle, the medication must be used within 6 weeks. After this time, the drug substance loses its validity.
The drug "Indocollyr" (eye drops): price and analogues
What can replace the drug in question? Among the analogues of this drug, the following medications can be distinguished: Indobene, Metindol, Indotard, Indovis EC, Indocide, Indomethacin, and so on. It should be specially noted that the properties and characteristics of these agents may differ from the properties and characteristics of the Indocollyr preparation. In this regard, they should be appointed only by a narrow specialist and only according to indications.
How much do Indocollyr eye drops cost? The price of this medication may be different. However, on average, the cost of the funds in question ranges from 260-300 Russian rubles. It should be noted that among the analogues of this medicine, drugs are much cheaper. Therefore, you can always replace it with an inexpensive, but no less effective means. But, as mentioned above, before this you should definitely consult with a specialist (that is, an optometrist or an ophthalmologist).